Uso de secuestrantes para disminuir la toxicidad de micotoxinas en alimentos para acuacultura
Palabras clave:
micotoxinas, alimentos, secuestrantes, biotransformadores, camarónResumen
La presencia de micotoxinas en alimentos para animales terrestres y acuáticos puede llegar a reducir significativamente el crecimiento, consumo de alimento, sobrevivencia e incrementar la tasa de conversión alimenticia así como causar afeccciones en el sistema inmune, por lo que pueden ser responsables de pérdidas económicas considerables. Para prevenir la contaminación de los ingredientes con micotoxinas durante su cultivo, cosecha y almacenamiento se han utilizado un sin número de procedimientos como buenas prácticas agrícolas, selección de semillas resistentes al ataque de hongos y a la formación de micotoxinas, uso de compuestos químicos durante el almacenamiento, remoción de micotoxinas por procesos físicos, etc., no obstante, en algunas ocasiones no se logra impedir la generación de estas toxinas. La inclusión de remediadores como: secuestrantes, biotransformadores y compuestos protectores son otras alternativas que permiten reducir al máximo la presencia de estas sustancias en los alimentos terminados o disminuir los estragos cuando los animales consumen alimentos contaminados con micotoxinas. En este trabajo se presenta una revisión general del uso de estos productos en alimentos para animales terrestres y acuáticos, incluyendo estudios de su efectividad in vivo así como consideraciones importantes al momento de incluirse en alimentos terminados.Descargas
Citas
Aoudia, N., Callu, P., Grosjean, F., Larondelle, Y. 2009. Effectiveness of mycotoxin sequestration activity of micronized wheat fibres on distribution of ochratoxin A in plasma, liver and kidney of piglets fed a naturally contaminated diet. Food Chem Toxicol. 47(7), 1485-1489.
Avantaggiato, G., Solfrizzo, M., Visconti, A. 2005. Recent advances on the use of adsorbent materials for detoxification of Fusarium mycotoxins.Food Additives and Contaminants 22(4), 379–388.
Awad, W.A., Böhm, J., Razzazi-Fazeli, E., Zentek, J. 2006. Effects of feeding deoxynivalenol contaminated wheat on growth performance, organ weights and histological parameters of the intestine of broiler chickens. Journal of Animal Physiology & Animal Nutrition 90(1/2), 32-37
Bautista M.N., Lavilla-Pitogo C.R., Subosa, P.F., Begino, E.T. 1995. Aflatoxin B1 contamination of shrimp feeds and its effect on growth and hepatopancreas of pre-adult Penaeus monodon. J. Sc. Food Agric. 65(1), 5-11.
Berthiller, F., Schuhmacher, R., Adam, G., Krska, R. 2009. Formation, determination and significance of masked and other conjugated mycotoxins. Anal Bioanal Chem. 395(5), 1243-1252.
Boonyaratpalin, M., Supamattaya, K., Verakunpiriya, V., Supraser, D. (2001) Effects of aflatoxin B1 on growth performance, blood components, immune function and histopathological changes in black tiger shrimp (Penaeus monodon Fabricius). Aquaculutre Research 32 (supplement 1), 388-398.
Boudergue, C., Burel, Ch., Dragacci, S., Favrot, M. Ch., Fremy, J.M., Massimi, C., Prigent, P., Debongnie, P., Pussemier, L., Boudra, H., Morgavi, D., Oswald, I., Perez, A., Avantaggiato, G. 2009. Review of mycotoxin-detoxifying agents used as feed additives: mode of action, efficacy and feed/food safety. Scientific report submitted to EFSA. 192 p. Reference number of the call for proposal: CFP/EFSA/FEEDAP/2009/01.
Borutova, R., Faix, S., Placha, I., Gresakova, L., Cobanova, K., Leng, L. 2008. Effects of deoxynivalenol and zearalenone on oxidative stress and blood phagocytic activity in broilers. Archives of Animal Nutrition 62(4), 303–312
Breinholt, V., Arbogast, D., Loveland, P., Pereira, C., Dashwood, R., Hendricks, J., Bailey, G. 1999. Chlorophyllin chemoprevention in trout initiated by aflatoxin B1 bath treatment: An evaluation of reduced bioavailability vs. target organ protective mechanisms. Toxicol. Appl. Pharmacol. 158, 141–151.
Broomhead,J.N., Ledoux, R.D., Bermudez, A.J., Rottinghaus, G.E. 2002. Chronic effects of fumonisin B1 in broilers and turkeys fed dietary treatments to market age. Poultry Science 81, 56-61.
Bundit, O., Kanghae, H., Phromkunthong, W., Supamattaya, K. 2006. Effects of mycotoxin T-2 and zearalenone on histopathological changes in black tiger shrimp (Penaeus monodon Fabricius). Songklanakarin Journal of Science and Technology 28(5), 937-949.
Cam, T.D., Encarnação, P., Hung, L.T. 2010. Aflatoxin B1 reduces growth performance, physiological response and disease resistance in Tra catfish (Pangasius hypophtha). In the 14th international symposium on fish nutrition and feeding, Program and abstracts P-189, pag. 341. May 31 to June 4, 2010, Qingdao, China.
Carson, M.S., Smith, T.K. 1983. Role of bentonite in prevention of T-2 toxicosis in rats. J Anim Sci 57,1498-1506.
Carlson, D.B., Williams, D.E., Spitsbergen, J.M., Ross, P.F., Bacon, C.W., Meredith, F.I., Riley, R.T. 2001. Fumonisin B1 promotes aflatoxin B1 and N-methyl-N'-nitro-nitrosoguanidine-initiated liver tumors in rainbow trout. Toxicol Appl Pharmacol. 172(1), 29-36.
Castaing, J. 1998. Uso de las arcillas en alimentación animal. XIV Curso de Especialización FEDNA: Avances en Nutrición y Alimentación Animal. Fundación Española para el Desarrollo de la Nutrición Animal. Eds.: P.Gª. Rebollar, C. de Blas y G.G. Mateos. Fira de Barcelona, España. 141-158 p.
Dänicke, S., Goyarts, T., Valenta, H. 2007. On the specific and unspecific effects of a polymeric glucomannan mycotoxin adsorbent on piglets when fed with uncontaminated or with Fusarium toxins contaminated diets. Archives of Animal Nutrition61(4), 266-275.
Dashwood, R., Negishi, T., Hayatsu, H., Breinholt, V., Hendricks, J., Bailey, G. 1998. Chemopreventive properties of chlorophylls towards aflatoxin B1 a review of the antimutagenicity and anticarcinogenicity data in rainbow trout Mutation Research 399, 245–253.
Denli, M., Okan, F., Doran, F., İnal, T. C. 2005. Effect of dietary conjugated linoleic acid (CLA) on carcass quality, serum lipid variables and histopathological changes of broiler chickens infected with aflatoxin B1. South African Journal of Animal Science 35 (2), 109-116.
Denli, M., Okan, F. 2006. Efficacy of different adsorbents in reducing the toxic effects of aflatoxin B1 in broiler diets. South African Journal of Animal Science 36 (4), 222-228.
Denli, M., Blandon, J.C., Guynot, M.E., Salado, S., Perez, J.F. 2009. Effects of dietary AflaDetox on performance, serum biochemistry, histopathological changes, and aflatoxin residues in broilers exposed to aflatoxin B1. Poultry Science 88, 1444–1451.
Dersjant-Li, Y., Verstegen, M.W.A., Gerrits, W.J.J. 2003. The impact of low concentrations of aflatoxin, deoxynivalenol or fumonisin in diets on growing pigs and poultry. In: Nutrition Research Review 16, 223-239. Cambridge University Press.
Díaz-Llano, G., Smith, T.K. 2006. Effects of feeding grains naturally contaminated with Fusarium mycotoxins with and without a polymeric glucomannan mycotoxin adsorbent on reproductive performance and serum chemistry of pregnant gilts. J Anim Sci 84, 2361-2366.
Diaz, D. 2005. The Mycotoxin Blue Book. Nottingham University Press, 349 pp.
Dong, M., He, X.J., Tulayakul, P., Li, J.-Y., Dong, K.-S., Manabe, N., Nakayama, H., Kumagai, S. 2010. The toxic effects and fate of intravenously administered zearalenone in goats. Toxicon 55(2/3), 523-530.
Dӧll, S., Gericke, S., Dänicke, S., Raila, J., Ueberschär, K.H., Valenta, H., Schnurrbusch, U., Schweigert, F.J., Flachowsky, G. 2005. The efficacy of a modified aluminosilicate as a detoxifying agent in Fusarium toxin contaminated maize containing diets for piglets. Journal of Animal Physiology and Animal Nutrition 89, 342-358.
Dӧll, S., Baardsen, G., Mӧller, P., Koppe, W. Stubhaug, I., Dänicke, S. 2010. Effects of increasing concentrations of mycotoxins deoxynivalenol, zearalenone or ochratoxin A in diets for Atlantic salmon (Salmo salar) on growth performance and health. In the 14th international symposium on fish nutrition and feeding, Program and abstracts O.074, pag 120. May 31 to June 4, 2010, Qingdao, China.
El-Barbary, M.I. 2008. Aflatoxin B Induced-Changes in Protein Electrophoretic Pattern and DNA in Oreochromis niloticus with Special Emphasis on the Protective Effect of Rosemary and Parsley Extracts. American-Eurasian J. Agric. & Environ. Sci., 4 (3): 381-390.
El-Barbary, M.I., Mehrim, A.I. 2009. Protective Effect of Antioxidant Medicinal Herbs, Rosemary and Parsley, on Subacute Aflatoxicosis in Oreochromis niloticus. Journal of Fisheries and Aquatic Science, 4(4), 178-190.
Ellis, R.W., Clements, M., Tibbetts, A., Winfree, R. 2000. Reduction of the bioavailability of 20 mgrkg aflatoxin in trout feed containing clay. Aquaculture 183, 179–188.
El-Sayed, Y.S., Khalil, R.H., Saad, T.T. 2009. Acute toxicity of ochratoxin-A in marine water-reared sea bass (Dicentrarchus labrax L.). Chemosphere 75, 878–882.
Eya, J.C., Parsons, A., Haile, I., Jagidi, P. 2008. Effects of dietary zeolites (Bentonite and Mordenite) on the performance juvenile Rainbow trout Onchorhynchus myskis. Australian Journal of Basic and Applied Sciences 2(4), 961-967.
Fink-Gremmels, J. 1999. Mycotoxins: their implications for human and animal health. Vet Q. 21(4), 115-120.
Frankic, T., Pajk, T., Rezar, V., Levart, A., Salobir, J. 2006. The role of dietary nucleotides in reduction of DNA damage induced by T-2 toxin and deoxynivalenol in chicken leukocytes. Food Chem Toxicol. 44(11), 1838-1844.
Galindo, J., Jaime, B., Fraga, I., Alvarez, J.S., 2006. Empleo de la zeolita en la alimentación del camarón blanco Litopenaeus schmitti. Comunicación Científica - CIVA 2006 (http://www.civa2006.org), 106-112.
Garaleviciene, D., Pettersson, H., Elwinger, K. 2002. Effects on health and blood plasma parameters of laying hens by pure nivalenol in the diet. J. Anim. Physiol. a. Anim. Nutr. 86, 389-398
Ghahri, H., Talebi, A., Chamani, M., Lotfollahian, H., Afzali, N. 2009. Ameliorative effect of esterified glucomannan, sodium bentonite, and humic acid on humoral immunity of broilers during chronic aflatoxicosis. Turk. J. Vet. Anim. Sci. 33(5), 419-425.
Gimeno, A., Martins, M.L. 2007. Micotoxinas y micotoxicosis en animales y humanos. © 2006 by SPECIAL NUTRIENTS, INC. 2766 SW Douglas Road, Miami, FL 33133 USA.Traducciones Victor Mireles , Ciudad de México, México. Julio 2007. 128 p.
Gopinath, R., Raj, R.P. 2009. Histological alterations in the hepatopancreas of Penaeus monodon Fabricius (1798) given aflatoxin B1-incorporated diets. Aquaculture Research 40(11), 1235 - 1242
Gowda, N.K.S., Ledoux, D. R., Rottinghaus, G.E., Bermudez, A.J., Chen, Y.C. 2008. Efficacy of turmeric (Curcuma longa), containing a known level of curcumin, and a hydrated sodium calcium aluminosilicate to ameliorate the adverse effects of aflatoxin in broiler chicks. Poultry Science 87, 1125–1130.
Guarisco, J.A., Hall, J.O., Coulombe, R.A. Jr. 2008. Mechanisms of butylated hydroxytoluene chemoprevention of aflatoxicosis - inhibition of aflatoxin B1 metabolism. Toxicol Appl Pharmacol. 227(3), 339-346.
Gupta, S., Jindal, N., Khokhar, R.S., Rajesh, R., Asrani, R.K., Ledoux, D.R., Rottinghaus, G.E. 2008. Individual and combined effects of ochratoxin A and Salmonella enterica serovar Gallinarum infection on pathological changes in broiler chickens. Avian Pathology 37(3), 265-272
Gutzwiller, A., Czeglédi, L., Stoll, P., Bruckner, L. 2007. Effects of Fusarium toxins on growth, humoral immune response and internal organs in weaner pigs, and the efficacy of apple pomace as an antidote. J Anim Physiol Anim Nutr (Berl). 91(9-10), 432-438.
Harvey, R.B., Kubena, L.F., Elissalde, M.H., Corrier, D.E., Huff, W.E., Rottinghaus, G.E., Clement, B.A. 1991. Cocontamination of swine diets by aflatoxin and diacetoxyscirpenol. J Vet Diagn Invest 3, 155-160.
Henry, M.H., Wyatt, R.D., Fletcher, O.J. 2000. The toxicity of purified fumonisin B1 in broiler chicks. 2000 Poultry Science 79, 1378-1384
Hooft, J., Bureau, D.P. 2010. Mycotoxins In feed affect fish health, performance. Aquaculture Avocate magazzine. The Global Aquaculture Alliance. Issue March-April 2010, 31-32.
House, J. D., Abramson, D., Crow, G.H., Nyachoti, C.M. 2002. Feed intake, growth and carcass parameters of swine consuming diets containing low levels of deoxynivalenol from naturally contaminated barley. Canadian Journal of Animal Science 82, 559-565.
Hussein, H.S., Brasel, .JM. 2001. Toxicity, metabolism, and impact of mycotoxins on humans and animals. Toxicology 167(2), 101-134.
Huwig, A., Freimund, S., Kappeli, O., Dutler, H. 2001. Mycotoxin detoxification of animal feed by different adsorbents. Toxicol. Lett., 122, 179–188.
James, L.J., Smith, T.K., 1982. Effect of dietary alfalfa on zearalenone toxicity and metabolism in rats and swine. Journal of Animal Science, 55, 110-118.
Jouany, J.P., Yiannikouris, A., Bertin, G. 2005. The chemical bonds between mycotoxins and cell wall components of Saccharomyces cerevisiae have been identified. Archiva Zootechnica 8, 25-50.
Kabak, B., Dobson, A.D., Var, I. 2006. Strategies to prevent mycotoxin contamination of food and animal feed: a review. Crit Rev Food Sci Nutr. 46(8), 593-619.
Kabak, B., 2009. The fate of mycotoxins during thermal food processing. Journal of the Science of Food and Agriculture, 89, 549-554.
Kamalzadeh, A., Hosseini, A., Moradi, S. 2009. Effects of yeast glucomannan on performance of broiler chickens. Int. J. Agric. Biol., 11(1), 49–53.
Kubena, L.F., Harvey, R.B., Bailey, R.H., Buckley, S.A. Rottinghaus, G.E. 1998. Effects of a hydrated sodium calcium aluminosilicate (T-Bindä) on mycotoxicosis in young broiler chickens. Poultry Science 77, 1502-1509.
Landeros, P., Reyes, W.P., deLucas, E., Albarrán, E., López, Y., Quezada, T. 2008. Evaluación de dos adsorbentes (manano oligosacáridos y clinoptilolita) en dietas de pollos de engorde contaminadas con fumonisina B1. Rev. Salud Anim. 30(1), 50-58.
Lawlor, P.G., Lynch, P.B. 2001. Mycotoxins in pig feeds 1: source of toxins, prevention and management of mycotoxicosis. Peer review 54(3), 117-120.
Leung, M.C., Diaz-Llano, G., Smith, T.K. 2006. Mycotoxins in pet food: a review on worldwide prevalence and preventative strategies. J Agric Food Chem. 54(26), 9623-9635.
Lightner, D.V., Redman, R.M. 1985. Necrosis of the hepatopancreas in Penaeus monodon and P. stylirostris (Arthropoda, Decapoda) with red disease. Journal of Fish Diseases 8, 181-188
Lim, H.A., Ng, W.K., Lim, S.L., Ibrahim, C.O. 2001. Contamination of palm kernel meal with Aspergillus Flavus affects its nutritive value in pelleted feed for tilapia, Oreochromis mossambicus. Aquaculture Research, 32, 895-905
Lopes, P.R.S., Pouey, J.L.O.F., Enke, D.B.S., Mallmann, C.A., Kich, H.A., Soquetta, M.B. 2009. Utilização de adsorvente em rações contendo aflatoxina para alevinos de jundiá. R. Bras. Zootec. 38(4), 589-595.
Madhusudhanan, N., Kavithalakshmi, S.N., Shanmugasundaram, E.R.B., Shanmugasundaram, K. R. 2006. Aflatoxin B1-Induced DNA Damage in Labeo rohita: Protective Effect of an Antioxidant Supplement, Amrita Bindu. Basic & Clinical Pharmacology & Toxicology, 98, 473-479.
Malagutti, L., Zannotti, M., Scampini, A., Sciaraffia, F. 2005. Effects of Ochratoxin A on heavy pig production. Anim. Res. 54, 179-184.
Manning, B.B., Li, M.H., Robinson, E.H., Gaunt, P.S., Camus, A.C., Rottinghaus, G.E. 2003. Response of channel catfish to diets containing T-2 toxin. Journal of Aquatic Animal Health 15, 229-238
Manning, B.B., Terhune, J.S., Li, M.H., Robinson, E.H., Wise, D.J., Rottinghaus, G.E. 2005. Exposure to feedborne mycotoxins T-2 toxin or ochratoxin a causes increased mortality of channel catfish challenged with Edwardsiella ictaluri. Journal of Aquatic Animal Health 17(2), 147-152
Markham, R.J.F., Erhardt, N.P., Dininno, V.L., Penman, D., Bhatti, A.R. 1987. Flavonoids protect against T-2 mycotoxins both in vitvo and in vivo. Journal of General Microbiologj 133, 1589- 1592
Marnewick, J.L., van der Westhuizen, F.H., Joubert, E., Swanevelder, S., Swart, P., Gelderblom, W.C. 2009. Chemoprotective properties of rooibos (Aspalathus linearis), honeybush (Cyclopia intermedia) herbal and green and black (Camellia sinensis) teas against cancer promotion induced by fumonisin B1 in rat liver. Food Chem Toxicol. 47(1), 220-229.
Mexía-Salazar, A.L., Hernández-López, J., Burgos-Hernández, A., Cortez-Rocha, M.O., Castro-Longoria, R., Ezquerra-Brauera, J. M. 2008. Role of fumonisin B1 on the immune system, histopathology, and muscle proteins of white shrimp (Litopenaeus vannamei). Food Chemistry 110(2), 471-479.
Miazzo, R., Rosa, C.A.R., De Queiroz Carvalho, E.C., Magnoli, C., Chiacchiera, S.M., Palacio, G., Saenz, M., Kikot, A., Basaldella, E., Dalcero, A. 2000. Efficacy of synthetic zeolite to reduce the toxicity of aflatoxin in broiler chicks. Poultry Science 79, 1-6.
Mitchell, J. K. 1993. Fundamentals of Soil Behavior. Second edition. New York, John Wiley & Sons, Inc. 437p.
Mohapatra, S., Sahu, N.P., Pal, A.K., Prusty, A.K., Kumar, V., Kumar, S. 2010. Haemato-immunology and histo-architectural changes in Labeo rohita fingerlings: effect of dietary aflatoxin and mould inhibitor. Fish Physiology and Biochemistry 10.1007/s10695-010-9428-1.
Mumpton, F.A., Fishman, P.H. 1977. The application of natural zeolites in animal science and aquaculture. Journal of Animal Science 45(5), 1188-1203.
Naaz, F., Javed, S., Abdin, M. Z. 2007. Hepatoprotective effect of ethanolic extract of Phyllanthus amarus Schum. et Thonn. on aflatoxin B1-induced liver damage in mice. J Ethnopharmacol. 113(3), 503-509.
Nieto-López, M.G., Medina, J.C., Rique-Marie, D., Tapia-Salazar, M., Guajardo-Barbosa, C., Cruz-Suárez, L.E. 2007. Efecto de la zearalenona y de un organoaluminosilicato en rendimiento de camarón blanco. XIII Congreso Bienal AMENA 2007. 23-26 Octubre, 2007. World Trade Center, Boca del Río Veracruz, México.
Nguyen, Q. T., Ogle, B., Pettersson, H. 2008. Efficacy of bentonite clay in ameliorating aflatoxicosis in piglets fed aflatoxin contaminated diets. Trop Anim Health Prod. 40, 649–656.
Offord, E.A., Mace, K., Avant, O., Pfefer, A.M.A. 1997. Mechanisms involved in the chemprotective effects of rosemary extract studied in human liver and branchial cells. Cancer Letters 114, 275-281.
Oguz, H., Kurtoglu, V. 2000. Effect of clinoptilolite on performance of broiler chickens during experimental aflatoxicosis. British Poultry Science 41, 512–517
Ostrowski-Meissmer, H.T., LeaMaster, B.R., Duerr, E.O., Walsh, W.A. 1995. Sensivity of the pacific white shrimp, Penaeus vannamei, to aflatoxin B1. Aquaculture 131, 155-164.
Ottinger, C.A., Kaattari, S.L. 2000. Long-term immune dysfunction in rainbow trout (Oncorhynchus mykiss) exposed as embryos to aflatoxin B1. Fish and Shellfish Immunology 10, 101-106.
Overy, D.P., Seifert, K.A., Savard, M.E., Frisvad, J.C. 2003. Spoilage fungi and their mycotoxins in commercially marketed chestnuts. Int J Food Microbiol. 88(1), 69-77.
Pettersson, H. 2004. Controlling mycotoxins in animal feed. In Mycotoxins in food: Detection and control. Edited by M Magan and M Olsen. Woodhead Publishing. ISBN 1855737337. Chapter 12, 43 pp.
Petrinec, Z., Pepeljnjak, S., Kovacic, S., Krznaric, A. 2004. Fumonisin B1 causes multiple lesions in common carp (Cyprinus carpio). Dtsch Tierarztl Wochenschr. 111(9), 358-63.
Pier, A. C., Richard, J. L., Cyzewski, S. J. 1980. Implications of mycotoxins in animal disease, J Am Vet Med Assoc, 176, 719–724.
Pimpukdee, K., Kubena, L.F., Bailey, C.A., Huebner, H.J., Afriyie-Gyawu, E., Phillips, T.D. 2004. Aflatoxin-induced toxicity and depletion of hepatic vitamin A in young broiler chicks: protection of chicks in the presence of low levels of NovaSil plus in the diet. Poultry Science 83, 737-744.
Raju, M.V.L.N., Devegowda, G. 2000. Influence of esterified-glucomannan on performance and organ morphology, serum biochemistry and haematology in broilers exposed to individual and combined mycotoxicosis (aflatoxin, ochratoxin and T-2 toxin). British Poultry Science 41, 640-650.
Raju, M.V.L.R., Rama, S.V., Radhika, R.K., Panda, A.K. 2005. Effect of amount and source of supplemental dietary vegetable oil on broiler chickens exposed to aflatoxicosis. British Poultry Science 46 (5), 587–594.
Ramos, A.J., Hernández, E. 1996. In vitro aflatoxin adsorption by means of a montmorillonite silicate. A study of adsorption isotherms. Anim. Feed Sci. Technol. 62, 263-269.
Renzulli, C., Galvano, F., Pierdomenico, L., Speroni, E., Guerra, M.C. 2004. Effects of rosmarinic acid against aflatoxin B1 and ochratoxin-A-induced cell damage in a human hepatoma cell line (Hep G2). J Appl Toxicol. 24(4), 289-296.
Sahoo, P.K., Mukherjee, S.C. 2001a. Effect of dietary β-1,3 glucan on immune responses and disease resistance of healthy and aflatoxin B1-induced immunocompromised rohu (Labeo rohita Hamilton). Fish & Shellfish Immunology 11, 683–695.
Sahoo, P.K., Mukherjee, S.C. 2001b. Dietary intake of levamisole improves non-specific immunity and disease resistance of healthy and aflatoxin induced immunocompromised rohu, Labeo rohita. Journal of applied aquaculture 11(4), 15-25.
Sahoo, P.K., Mukherjee, S.C. 2002. Influence of high dietary a-tocopherol intakes on specific immune response, nonspecific resistance factors and disease resistance of healthy and aflatoxin B1-induced immunocompromised Indian major carp, Labeo rohita (Hamilton). Aquaculture Nutrition 8, 159-167
Sahoo, P.K., Mukherjee, S.C. 2003. Immunodulation by dietary vitamin C in healthy and aflatoxin B1 induced immunocompromised rohu (Labeo rohita). Comparative Immunology, Microbiology and infectious Diseases 26, 65-76.
Sakhare, P. S., Harne, S.D., Kalorey, D.R., Warke, S.R., Bhandarkar, A.G., Kurkure, N.V. 2007. Effect of Toxiroak polyherbal feed supplement during induced aflatoxicosis, ochratoxicosis and combined mycotoxicoses in broilers. Vet. arhiv 77, 129-146.
Santin, E., Maiorka, A., Krabbe, E.L., Paulillo, A.C., Alessi, A.C. 2002. Effect of hydrated sodium calcium aluminosilicate on the prevention of the toxic effects of ochratoxin. J. Appl. Poult. Res. 11, 22-28.
Santurio, J.M., Mallmann, C.A., Prosa, A., Appel, G., Heer, A., Dagefӧrde, S., Bӧttcher, M. 1999. Effect of sodium bentonite on the performance and blood variables of broiler chickens intoxicated with aflatoxins. British Poultry Science 40, 115–119.
Schell, T.C., Lindemann, M.D., Kornegay, E.T., Blodgett, D.J. 1993. Effects of feeding aflatoxin-contaminated diets with and without clay to weanling and growing pigs on performance, liver function, and mineral metabolism. J Anim Sci. 71, 1209-1218.
Shehata, S.A., El-Melegy, Kh.M., Ebrahim M.S. 2009. Toxicity Reduction of Aflatoxin B1 by Vitamin C in Fish. Journal of the Arabian Aquaculture Society 4(2), 73-86.
Shi, Y. H., Xu, Z.R., Wang, Ch. Z., Sun, Y. 2007. Efficacy of two different types of montmorillonite to reduce the toxicity of aflatoxin in pigs. New Zealand Journal of Agricultural Research 50, 473-478.
Shi, Y. 2008. Mechanisms of polyunsaturated fatty acids inhibition of mycotoxin deoxidivalenol induce immune response. phD thesis Food science and environmental toxicology. Michigan State University, 184 p.
Simonich, M.T., McQuistan, T., Jubert, C., Pereira, C., Hendricks, J.D., Schimerlik, M., Zhu, B., Dashwood, R.H., Williams, D.E., Bailey, G.S. 2008. Low-dose dietary chlorophyll inhibits multi-organ carcinogenesis in the rainbow trout. Food Chem Toxicol. 46(3), 1014-1024.
Sinnhuber, R.O., Lee, D. J., Wales, H.J., Landers, M.K., Key, A.C. 1974. Hepatic carcinogenesis of aflatoxin M1 in rainbow trout Salmo gairdneri. and its enhancement by cyclo-propene fatty acids, J. Natl. Cancer Inst. 53, 1285–1288.
Smith, T.K., McMillan, E.G., Castillo, J.B. 1997. Effect of feeding blends of Fusarium mycotoxin-contaminated grains containing deoxynivalenol and fusaric acid on growth and feed consumption of immature swine. J Anim Sci 75, 2184-2191.
Smith, G.W., Constable, P.D., Eppley, R.M., Tumbleson, M.E., Gumprecht, L.A., Haschek-Hock, W.M. 2000. Purified fumonisin B1 decreases cardiovascular function but does not alter pulmonary capillary permeability in swine. Toxicological Sciences 56, 240-249.
Soonngam, Ch. A. L., Hutacharoen, R. 2007. Vermiculite and hydrated sodium calcium aluminosilicates as the agent of aflatoxin b1 absorption for black tiger shrimp diets. Environment and Natural Resources Journal 5(1), 50-58.
Stangroom, K.E., Smith, T.K., 1984. Effect of whole and fractionated dietary alfalfa meal on zearalenone toxicosis in rats and swine. Can. J. Physiol. Pharmacol. 62, 1219-1224.
Supamattaya K., Sukrakanchana N., Boonyaratpalin M., Schatzmayr D., Chittiwan V. 2005. Effects of ochratoxin A and deoxynivalenol on growth performance and immuno-physiological parameters in black tiger shrimp (Penaeus monodon). Songklanakarin Journal of Science and Technology 27, 91-99.
Swamy, H.V.L.N., Smith, T.K., MacDonald, E.J., Boermans, H.J., Squires, E.J. 2002. Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on swine performance, brain regional neurochemistry, and serum chemistry and the efficacy of a polymeric glucomannan mycotoxin adsorbent. J Anim. Sci., 80, 3257-3267.
Swamy, H.V., Smith, T.K., MacDonald, E.J., Karrow, N.A., Woodward, B., Boermans, H.J. 2003. Effects of feeding a blend of grains naturally contaminated with Fusarium mycotoxins on growth and immunological measurements of starter pigs, and the efficacy of a polymeric glucomannan mycotoxin adsorbent. J Anim Sci. 81(11), 2792-803.
Takagi, M., Mukai, S., Kuriyagawa, T., Takagaki, K., Uno, S., Kokushi, E., Otoi, T., Budiyanto, A., Shirasuna, K., Miyamoto, A., Kawamura, O., Okamoto, K., Deguchi, E. 2008. Detection of zearalenone and its metabolites in naturally contaminated follicular fluids by using LC/MS/MS and in vitro effects of zearalenone on oocyte maturation in cattle. Reproductive Toxicology 26(2), 164-169.
Tedesco, D., Steidler, S., Galletti, S., Tameni, M., Sonzogni, O., Ravarotto, L. 2004. Efficacy of silymarin-phospholipid complex in reducing the toxicity of aflatoxin B1 in broiler chicks. Poultry Science 83, 1839-1843.
Tessari, E.N.C., Oliveira, C.A.F., Cardoso, A.L.S.P., Ledoux, D.R. Rottinghaus, G.E. 2006. Effects of aflatoxin B1 and fumonisin B1 on body weight, antibody titres and histology of broiler chicks. British Poultry Science 47(3), 357-364.
Tiemann, U., Daumlnicke, S. 2007. In vivo and in vitro effects of the mycotoxins zearalenone and deoxynivalenol on different non-reproductive and reproductive organs in female pigs: A review. Food Additives & Contaminants: Part A 24(3), 306 – 314.
Trigo-Stockli D.M., Obaldo L.G., Dominy W.G. & Behnke, K.C. (2000) Utilization of deoxynivalenol-contaminated hard red winter wheat for shrimp feeds. Journal of the World Aquaculture Society 31, 247-254.
Valdivia, A.G., Martínez, A., Damián, F.J., Quezada, T., Ortiz, R., Martínez, C., Llamas, J., Rodríguez, M.L., Yamamoto, L., Jaramillo, F., Loarca-Piña, M.G., Reyes, J.L. 2001. Efficacy of N-Acetylcysteine to reduce the effects of aflatoxin B1 intoxication in broiler chickens. Poultry Science 80, 727-734.
Wang, P., Afriyie-Gyawu, E., Tang, Y., Johnson, N., Xu, L., Tang, L., Huebner, H., Ankrah, N.-A., Ofori-Adjei, D., Ellis, R.W., Jolly, P., Williams, J., Wang, J.-S., Phillips, T.D., 2008. NovaSil clay intervention in Ghanaians at high risk for aflatoxicosis: II. Reduction in biomarkers of aflatoxin exposure in blood and urine. Food Additives and Contaminants, 25, 622-634.
Weaver, G.A., Kurtz, H.J., Bates, F.Y., Mirocha, C.J., Behrens, J.C., Hagler, W.M. 1981. Diacetoxyscirpenol toxicity in pigs. Res Vet Sci. 31(2), 131-5.
Weber, M., Balogh, K., Erdélyi, M., Mézes, M. 2006. Effect of T-2 toxin in combination with vitamin E, selenium and mycotoxin binder on lipid peroxide status and on the glutathione redox system in broiler chicken. The Journal of Poultry Science 43, 222-227.
Weber, M., Balogh, K., Fodor, J., Erdélyi, M., Ancsin, Z., Mézes, M. 2010. Effect of T-2 and HT-2 toxin during the growing period on body weight, lipid peroxide and glutathione redox status of broiler chickens. ACTA VET. BRNO 79, 27–31.
Willis, W.L., Quarles, C.L., Fagerberg, D.J. 1982 Evaluation of zeolites fed to male broiler chickens. Poultry Science 61, 438-442.
Wiseman MO, Price RL, Ligthner DV, Williams RR. 1982. Toxicity of Aflatoxin B1 to peneid shrimp. Appl. Environ. Microbiol. 44(6), 1479-1481.
Woodward B., Young L.G. & Lun A.K. (1983) Vomitoxin in diets for rainbow trout (Salmo gairdneri). Aquaculture 35, 93-101.
Yiannikouris, A., Andre, G., Poughon, L., Francois, J., Dussap, C. G., Jeminet, G., Bertin, G., Jouany, J.P. 2006. Chemical and conformational study of the interactions involved in mycotoxin complexation with ß-D-Glucans. Biomacromolecules 7, 1147–1155.
Yildrim M, Manning B.B., Lovell R.T., Grizzle J.M. & Rottinghaus, G.E. (2000) Toxicity of moniliformin and fumonisin B1 fed singly and in combination in diets for young channel catfish Ictalurus punctatus. Journal of the World Aquaculture Society 31, 599-608.