Non-coding RNAs: Uncovering their Potential Relevance in Fish Nutrition
Keywords:
ncRNAs, miRNAs, nutrigenomics, transcriptomics, NGSAbstract
The optimization of industrial production would only be possible with the discovery, identification and
characterization of biological processes in which a nutrient or any other factor acts, as well as when their
genes and genetic networks revealed. With the advent of Next Generation-Sequencing technologies, the
discovery of non-coding RNAs having a key role on the control of a diverse set of biological functions in
multicellular organism will allow a deeper knowledge on genes and genetic networks control such processes
in farmed fish species. Here, the basics of non-coding RNAs regarding their features, biogenesis and mode of
action will be briefly reviewed, while the research works specifically conducted until now on the
identification of non-coding RNAs in different farmed fish species, developmental stages and tissues using
high throughput technologies will be described and compared. Several non-coding RNAs have been
associated with early developmental events, immune response to pathogen infections, sexual differentiation
and maturation, and nutrition. While the research on miRNAs is the most abundant, new efforts on the
characterization of long non-coding RNAs and PIWI-interacting RNAs profiles provided new insights on how
these non-coding RNAs are also involved in fish nutrition. Finally, the future perspectives and considerations
on the potential use of non-coding RNAs (mainly those found in circulation) in relevant cultured fish species
as new reliable biomarkers of physiological condition will be pointed out.
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